Publications

Granadier, D., Acenas, D., 2nd, & Dudakov, J. A. (2025). Endogenous thymic regeneration: restoring T cell production following injury. Nature reviews. Immunology, 10.1038/s41577-024-01119-0. Advance online publication. https://doi.org/10.1038/s41577-024-01119-0

Acenas, D. V., 2nd, & Dudakov, J. A. (2023). Feeling at home: Identifying a human thymic epithelial progenitor cell niche. Developmental cell, 58(22), 2411–2412. https://doi.org/10.1016/j.devcel.2023.10.015

Kousa AI, Jahn L, Zhao K, Flores AE, Acenas D 2nd, Lederer E, Argyropoulos KV, Lemarquis AL, Granadier D, Cooper K, D’Andrea M, Sheridan JM, Tsai J, Sikkema L, Lazrak A, Nichols K, Lee N, Ghale R, Malard F, Andrlova H, Velardi E, Youssef S, Burgos da Silva M, Docampo M, Sharma R, Mazutis L, Wimmer VC, Rogers KL, DeWolf S, Gipson B, Gomes ALC, Setty M, Pe’er D, Hale L, Manley NR, Gray DHD, van den Brink MRM, Dudakov JA. Age-related epithelial defects limit thymic function and regeneration. Nat Immunol. 2024 Sep;25(9):1593-1606. doi: 10.1038/s41590-024-01915-9. Epub 2024 Aug 7. PMID: 39112630; PMCID: PMC11362016.

Lovino L, Cooper K, deRoos P, Kinsella S, Evandy CA, Ugrai T, Mazziotta F, Iovino, L., Cooper, K., deRoos, P., Kinsella, S., Evandy, C. A., Ugrai, T., Mazziotta, F., Ensbey, K. S., Granadier, D., Hopwo, K., Smith, C. W., Gagnon, A., Galimberti, S., Petrini, M., Hill, G. R., & Dudakov, J. A. (2022). Activation of the Zinc-sensing receptor GPR39 promotes T cell reconstitution after hematopoietic cell transplant in mice. Blood, blood.2021013950.

Granadier, D., Iovino, L., Kinsella, S., & Dudakov, J. A. (2021). Dynamics of thymus function and T cell receptor repertoire breadth in health and disease. Seminars in immunopathology, 43(1), 119–134. https://doi.org/10.1007/s00281-021-00840-5

Kinsella, S., Evandy, C. A., Cooper, K., Iovino, L., deRoos, P. C., Hopwo, K. S., Granadier, D. W., Smith, C. W., Rafii, S., & Dudakov, J. A. (2021). Attenuation of apoptotic cell detection triggers thymic regeneration after damage. Cell reports, 37(1), 109789. https://doi.org/10.1016/j.celrep.2021.109789

Wertheimer T, Velardi E, Tsai J, Cooper K, Xiao S, Kloss CC, Ottmüller KJ, Mokhtari Z, Brede C, deRoos P, Kinsella S, Palikuqi B, Ginsberg M, Young LF, Kreines F, Lieberman SR, Lazrak A, Guo P, Malard F, Smith OM, Shono Y, Jenq RR, Hanash AM, Nolan DJ, Butler JM, Beilhack A, Manley NR, Rafii S, Dudakov JA*, and van den Brink MRM*. Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. (2018) Science Immunology. Vol. 3, Issue 19, eaal2736

*Co-senior author
http://immunology.sciencemag.org/content/3/19/eaal2736.full

Velardi E, Tsai JJ, Stefan R, Cooper K, Argyropoulos K, Jae-Hung S, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq R, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM*, and Dudakov JA*. Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury. (2018) Nature Medicine. Vol. 24: 239–246.

*Co-senior author
https://www.nature.com/articles/nm.4470

Dudakov JA, Hanash AM, van den Brink MR. Interleukin-22: immunobiology and pathology. (2015) Ann. Rev Immunol. 2015;33:747-85.
http://www.annualreviews.org/doi/abs/10.1146/annurev-immunol-032414-112123

Velardi E, Tsai JJ, Holland AM, Wertheimer T, Yu VWC, Zakrzewski JL, Tuckett AZ, Singer NV, West ML, Smith OM, Young LF, Kreines FM, Levy ER, Boyd RL, Scadden DT, Dudakov JA*, and van den Brink MRM*. Sex steroid blockade enhances thymopoiesis by modulating Notch signaling. (2014) J. Exp. Med. 211:2341-2349. PMID: 25332287. PMCID: PMC4235646

* Co-senior author
http://jem.rupress.org/content/early/2014/10/15/jem.20131289.abstract

Dudakov JA, Hanash AM, Jenq RR, Young LF, Ghosh A, Singer NV, West ML, Smith OM, Holland AM, Tsai JJ, Boyd RL, and van den Brink MRM. Interleukin-22 drives endogenous thymic regeneration in mice. (2012) Science. 336:91-95. http://www.sciencemag.org/content/336/6077/91.abstract